Fractional CO2 Laser Resurfacing Complications
The development of CO2 lasers was motivated by the desire to achieve excellent results while maintaining a favorable sideeffect profile. Although significant side effects are relatively uncommon, they do occur and occasionally may be severe. Understandably, cosmetic surgery patients have less tolerance of side effects than patients undergoing medically indicated procedures. The astute surgeon will learn to prevent, promptly recognize, and treat these side effects.
Infection An intact skin barrier is the best layer of defense against infection. By definition, fractionated ablative CO2 laser resurfacing perforates the skin barrier allowing for a potential infection postprocedure. The pathologic organisms that may infect the skin include bacteria, fungi, and viruses. The most common cause of scarring is postoperative infection, which usually presents several days postoperatively as a localized area of delayed healing.
Inexperienced or inattentive surgeons as well as patients may find it difficult to distinguish infection from the normal healing process. When an infection is suspected, it is advised to promptly perform microbiologic culture testing to identify the organism and determine its sensitivity to treatment. The most common causes of infection include Staphylococcus, Pseudomonas, Klebsiella, and Enterobacter. Candidiasis may be quite subtle and present as prolonged erythema and pruritus.1,2 Herpes simplex virus may disseminate over the entire face without prophylaxis.
Atypical mycobacterial infection has also been reported and may present as papules or nodules.3,4 Most patients are prescribed a course of both antibiotic and antiviral medications. The antibiotic is usually selected for Staphylococcus coverage and the antiviral for herpes simplex. Systemic antibiotics are preferable to most topical antibiotics due to the possibility of allergic contact dermatitis, especially to neomycin, polymyxin, and bacitracin.5 Postoperative steroid usage immediately after resurfacing is controversial due to increased infection risk. Of note, recently two cases of infection presumably caused by the substitution postoperatively of a potent topical steroid in place of petrolatum have been reported.6
Scarring and Ectropion The most dreaded side effect, of course, is scarring.7,8 Manuskiatti documented a 3.8% incidence of scarring.9 In this series, every case was caused by infection, highlighting the need for surveillance, and proper skin care including possible antibiotic and antiviral prophylaxis. Another cause of scarring represents operator error in the form of excessive fluence or density, too many passes, or pulse stacking.10 If the skin is heated beyond its ability to heal promptly and without excessive fibrosis, scarring will occur .
The neck and chest are more susceptible to scarring than the face and must be treated with caution.
Ectropion may be the result of cicatrix, but usually results from excessive fluence or density on the thin and highly contractile skin of the lower eyelids.8 Patients with previous subciliary lower blepharoplasty, scleral show, large globes, and lax lower eyelids are particularly prone .
Koebnerization Any dermatosis that Koebnerizes may be initiated by laserinduced trauma. This includes diseases such as vitiligo and psoriasis .
Eruptive keratoacanthomas have been reported, presumably secondary to Koebnerization.12,13 Dyschromia Temporary hyperpigmentation, so common following previous generation CO2 lasers in skin types IV and V, is less likely with fractional resurfacing assuming reasonable treatment parameters .14 Fortunately, delayed-onset permanent hypopigmentation seen in up to 19% of cases with previous generation CO2 lasers is very uncommon.15–19 Nevertheless, fractional lasers are certainly capable of damaging the skin enough to cause excessive fibrosis and disruption of melanogenesis, the causes of hypopigmentation.
Contact Dermatitis Postoperative contact dermatitis may be either irritant or allergic in nature. Perforation of the skin barrier may promote this side effect. It can be particularly challenging to distinguish contact dermatitis from infection while the patient’s skin is red and edematous due to expected laser healing.
Even in the prefractionated resurfacing era, it was recognized that a wide variety of creams, ointments, cleansers, and other skin care products may cause contact dermatitis after laser resurfacing.20 If a product is suspected to be a culprit, it should be discontinued immediately. Of special note, as previously mentioned, topical antibiotics such as neomycin, bacitracin, and polymyxin have been discouraged due to the heightened risk of allergic contact dermatitis. Bacitracin has been reported to cause not only contact dermatitis postresurfacing, but also foreign body granulomas due to its mineral oil content.5,21 It should be mentioned that “natural” or “botanical” products can definitely cause contact dermatitis despite the gentle nature implied
Prolonged Erythema Prolonged erythema, so common with previous lasers, is uncommon. It can be caused by inappropriate laser settings, infection, aggressive debridement between laser passes, and contact dermatitis.
Over time, postresurfacing erythema fades gradually. Optionally, the usage of a pulsed dye laser or intense pulsed light device may be helpful in reducing the redness more quickly. Other Acne and milia are common minor side effects.16,19,22 Spontaneous resolution can be expected. If bothersome to the patient, milia may be removed via extraction or pinpoint electrodessication. Acne treatment must be administered carefully as the recently reepitheliazed skin is temporarily more sensitive after resurfacing
References
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2 Conn H, Nanda VS. Prophylactic fluconazole promotes reepithelialization in full-face carbon dioxide laser skin resurfacing. Lasers Surg Med 2000;26(2):201–207
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